Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling.

ABSTRACT:

Background

Airway remodeling in patients with asthma, which leads to a decline in pulmonary function, is likely the result of repeated exacerbations often provoked by aeroallergen exposures. Aeroallegen exposure triggers a stereotypic response orchestrated by growth factor cytokines and other protein mediators. This results in a late-phase allergic reaction characterized by vascular permeability, recruitment of activated leukocytes, and activation of structural cells of the airway. The spectrum of protein mediators and their functions are incompletely understood.

Methods

Bronchoalveolar lavage fluid (BALF) samples were obtained from 12 volunteers who exhibited robust eosinophilic recruitment following segmental bronchial provocation with allergen (SBP-Ag). We systematically

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9117591 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature