Altered performance monitoring in Tourette Syndrome: an MEG investigation.

ABSTRACT: The error-related negativity (ERN) is an event-related potential component indexing processes of performance monitoring during simple stimulus-response tasks: the ERN is typically enhanced for error processing and conflicting response representations. Investigations in healthy participants and different patient groups have linked the ERN to the dopamine system and to prefrontal information processing. As in patients with Tourette Syndrome (TS) both dopamine release and prefrontal information processing are impaired, we hypothesized that performance monitoring would be altered, which was investigated with magnetencephalography (MEG). We examined performance monitoring in TS patients by assessing the magnetic equivalent of the ERN (mERN). The mERN was investigated in tic-free trials of eight

SUBMITTER: Metzlaff J 

PROVIDER: S-EPMC9117680 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature