Current Treatment Approaches and Global Consensus Guidelines for Brain Metastases in Melanoma.

ABSTRACT:

Background

Up to 60% of melanoma patients develop melanoma brain metastases (MBM), which traditionally have a poor diagnosis. Current treatment strategies include immunotherapies (IO), targeted therapies (TT), and stereotactic radiosurgery (SRS), but there is considerable heterogeneity across worldwide consensus guidelines.

Objective

To summarize current treatments and compare worldwide guidelines for the treatment of MBM.

Methods

Review of global consensus treatment guidelines for MBM patients.

Results

Substantial evidence supported that concurrent IO or TT plus SRS improves progression-free survival (PFS) and overall survival (OS). Guidelines are inconsistent with regards to recommendations for surgical resection of MBM, since surgical resection of symptomati

SUBMITTER: Tan XL 

PROVIDER: S-EPMC9117744 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature