TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila.

ABSTRACT: When infected by enteric pathogenic bacteria, animals need to initiate local and whole-body defence strategies. Although most attention has focused on the role of innate immune anti-bacterial responses, less is known about how changes in host metabolism contribute to host defence. Using Drosophila as a model system, we identify induction of intestinal target-of-rapamycin (TOR) kinase signalling as a key adaptive metabolic response to enteric infection. We find that enteric infection induces both local and systemic induction of TOR independently of the Immune deficiency (IMD) innate immune pathway, and we see that TOR functions together with IMD signalling to promote infection survival. These protective effects of TOR signalling are associated with remodelling of host lipid metabolism. Thus

SUBMITTER: Deshpande R 

PROVIDER: S-EPMC9118046 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature