Proposing a Sex-Adjusted Sodium-Adjusted MELD Score for Liver Transplant Allocation.

ABSTRACT:

Importance

Liver allocation is determined by the model for end-stage liver disease (MELD), a scoring system based on 4 laboratory measurements. During the MELD era, sex disparities in liver transplant have increased and there are no modifications to MELD based on sex.

Objective

To use laboratory values stored in electronic health records to describe population-level sex differences in all MELD laboratory values (in healthy individuals and patients with liver disease) and propose a sex adjustment.

Design, setting, and participants

A retrospective cohort study was conducted from March 2019 to April 2020 to evaluate sex differences in laboratory values in liver transplant patients, patients with liver disease who did not undergo transplant, and healthy controls. Primary

SUBMITTER: Sealock JM 

PROVIDER: S-EPMC9118088 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature