A Randomized Controlled Trial of Combinatorial Pharmacogenetics Testing in Adolescent Depression.

ABSTRACT:

Objective

Numerous commercial pharmacogenetics panels are now widely available for clinical use in psychiatric practice. However, there is a paucity of literature evaluating the use of combinatorial pharmacogenetics panels to enhance outcomes in the treatment of adolescents with depression. This study sought to prospectively evaluate the clinical impact of combinatorial pharmacogenetics testing in a double-blind, randomized, controlled effectiveness study for the pharmacologic treatment of adolescents with depression.

Method

Adolescents aged 13 to 18 years (N = 176) with moderate to severe major depressive disorder (MDD) were randomized to treatment arm guided by testing in which pharmacogenetic testing results were available at the baseline visit (GENE arm, n = 84) or a tre

SUBMITTER: Vande Voort JL 

PROVIDER: S-EPMC9118122 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature