In vivo solid tumor targeting with recombinant VEGF-diphtheria immunotoxin.

ABSTRACT:

Objectives

A variety of signaling molecules have been identified that play a role in angiogenesis, of prime importance, vascular endothelial growth factor (VEGF) and its resceptor (VEGFR), which is highly expressed in most human solid tumors. Targeting VEGF or/and VEGFR with immunotoxin may be a promising approach to directly affect cancer cells. Immunotoxins are for targeted treatment comprising two functional moieties, an antibody that binds to target cells along with toxin that kills molecules.

Materials and methods

In this study, an immunotoxin comprising domain of diphtheria toxin subunit A (DT386) genetically fused to mouse VEGF (mVEGF-DT) was developed. The second construct, which contains the DT386 domain, was made to investigate the action of the DT386 domain on tum

SUBMITTER: Hosseininejad-Chafi M 

PROVIDER: S-EPMC9118281 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature