A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain.

ABSTRACT:

Study objective

The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain.

Design

Dose escalation clinical trial.

Setting

Outpatient.

Patients

Ten adult patients with uncontrolled cancer-related pain.

Intervention

Each patient received escalating doses of ketamine over four visits, each 2-5 days apart: 10 mg IN at visit 1, 10 mg intravenous (IV) at visit 2, 30 mg IN at visit 3, and 50 mg IN at visit 4.

Measurements

Pain was measured before and after drug administration for up to 4 h using the 11 point (0-10) Numerical Pain Rating Scale (NPRS).

Main results

All subjects had advanced cancer, with intractable pain, despite bei

SUBMITTER: Singh V 

PROVIDER: S-EPMC9118341 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature