Remote contextual fear retrieval engages activity from salience network regions in rats.

ABSTRACT: The ability to retrieve contextual fear memories depends on the coordinated activation of a brain-wide circuitry. Transition from recent to remote memories seems to involve the reorganization of this circuitry, a process called systems consolidation that has been associated with time-dependent fear generalization. However, it is unknown whether emotional memories acquired under different stress levels can undergo different systems consolidation processes. Here, we explored the activation pattern and functional connectivity of key brain regions associated with contextual fear conditioning (CFC) retrieval after recent (2 days) or remote (28 days) memory tests performed in rats submitted to strong (1.0 mA footshock) or mild (0.3 mA footshock) training. We used brain tissue from Wistar rats fr

SUBMITTER: Dos Santos Correa M 

PROVIDER: S-EPMC9118522 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature