¹³C¹⁵N: glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans.

ABSTRACT:

Background

Glucagon serves as an important regulatory hormone for regulating blood glucose concentration with tight feedback control exerted by insulin and glucose. There are critical gaps in our understanding of glucagon kinetics, pancreatic α cell function and intra-islet feedback network that are disrupted in type 1 diabetes. This is important for translational research applications of evolving dual-hormone (insulin + glucagon) closed-loop artificial pancreas algorithms and their usage in type 1 diabetes. Thus, it is important to accurately measure glucagon kinetics in vivo and to develop robust models of glucose-insulin-glucagon interplay that could inform next generation of artificial pancreas algorithms.

Methods

Here, we describe the administration of novel ¹³

SUBMITTER: Renuse S 

PROVIDER: S-EPMC9118570 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature