Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review.

ABSTRACT:

Background

Idiopathic Scoliosis (IS) is the most common spinal deformity in adolescents, accounting for 80% of all spinal deformities. However, the etiology remains uncertain in most cases, being identified as Adolescent Idiopathic Scoliosis (AIS). IS treatments range from observation and sport to bracing or surgery. Several risk factors including sex and familiarity, have been linked with IS. Although there are still many uncertainties regarding the cause of this pathology, several studies report a greater incidence of the defect in families in which at least one other first degree relative is affected. This study systematically reviews the available literature to identify the most significant genes or variants related to the development and onset of IS.

Methods

The researc

SUBMITTER: De Salvatore S 

PROVIDER: S-EPMC9118580 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature