Synthesis, molecular docking, and cytotoxicity of quinazolinone and dihydroquinazolinone derivatives as cytotoxic agents.

ABSTRACT:

Background

Cancer is the most cause of morbidity and mortality, and a major public health problem worldwide. In this context, two series of quinazolinone 5a-e and dihydroquinazolinone 10a-f compounds were designed, synthesized as cytotoxic agents.

Methodology

All derivatives (5a-e and 10a-f) were synthesized via straightforward pathways and elucidated by FTIR, ¹H-NMR, CHNS elemental analysis, as well as the melting point. All the compounds were evaluated for their in vitro cytotoxicity effects using the MTT assay against two human cancer cell lines (MCF-7 and HCT-116) using doxorubicin as the standard drug. The test derivatives were additionally docked into the PARP10 active site using Gold software.

Results and discussion

Most of the synthesized compounds,

SUBMITTER: Taayoshi F 

PROVIDER: S-EPMC9118628 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature