The heart-brain axis: A proteomics study of meditation on the cardiovascular system of Tibetan Monks.

ABSTRACT:

Background

There have been mixed reports on the beneficial effects of meditation in cardiovascular disease (CVD), which is widely considered the leading cause of death worldwide.

Methods

To clarify the role of meditation in modulating the heart-brain axis, we implemented an extreme phenotype strategy, i.e., Tibetan monks (BMI > 30) who practised 19.20 ± 7.82 years of meditation on average and their strictly matched non-meditative Tibetan controls. Hypothesis-free advanced proteomics strategies (Data Independent Acquisition and Targeted Parallel Reaction Monitoring) were jointly applied to systematically investigate and target the plasma proteome underlying meditation. Total cholesterol, low-density lipoprotein cholesterol  (LDL-C), apolipoprotein B (Apo B) and lipoprotein (a

SUBMITTER: Xue T 

PROVIDER: S-EPMC9118669 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature