Differentially methylated CpGs in response to growth hormone administration in children with idiopathic short stature.

ABSTRACT:

Background

Recombinant human growth hormone (rhGH) has shown a great growth-promoting potential in children with idiopathic short stature (ISS). However, the response to rhGH differs across individuals, largely due to genetic and epigenetic heterogeneity. Since epigenetic marks on the methylome can be dynamically influenced by GH, we performed a comprehensive pharmacoepigenomics analysis of DNA methylation changes associated with long-term rhGH administration in children with ISS.

Results

We measured DNA methylation profiles before and after GH treatment (with a duration of ~ 18 months in average) on 47 healthy children using customized methylC-seq capture sequencing. Their changes were compared and associated with changes in plasma IGF1 by adjusting sex, age, treatment dura

SUBMITTER: Shao X 

PROVIDER: S-EPMC9118695 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature