Dataset Information

Evaluation of statistical approaches for association testing in noisy drug screening data.

ABSTRACT:

Background

Identifying associations among biological variables is a major challenge in modern quantitative biological research, particularly given the systemic and statistical noise endemic to biological systems. Drug sensitivity data has proven to be a particularly challenging field for identifying associations to inform patient treatment.

Results

To address this, we introduce two semi-parametric variations on the commonly used concordance index: the robust concordance index and the kernelized concordance index (rCI, kCI), which incorporate measurements about the noise distribution from the data. We demonstrate that common statistical tests applied to the concordance index and its variations fail to control for false positives, and introduce efficient implementations to compute p-values using adaptive permutation testing. We then evaluate the statistical power of these coefficients under simulation and compare with Pearson and Spearman correlation coefficients. Finally, we evaluate the various statistics in matching drugs across pharmacogenomic datasets.

Conclusions

We observe that the rCI and kCI are better powered than the concordance index in simulation and show some improvement on real data. Surprisingly, we observe that the Pearson correlation was the most robust to measurement noise among the different metrics.

SUBMITTER: Smirnov P

PROVIDER: S-EPMC9118710 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Evaluation of statistical approaches for association testing in noisy drug screening data.

Smirnov Petr P Smith Ian I Safikhani Zhaleh Z Ba-Alawi Wail W Khodakarami Farnoosh F Lin Eva E Yu Yihong Y Martin Scott S Ortmann Janosch J Aittokallio Tero T Hafner Marc M Haibe-Kains Benjamin B

BMC bioinformatics 20220518 1

<h4>Background</h4>Identifying associations among biological variables is a major challenge in modern quantitative biological research, particularly given the systemic and statistical noise endemic to biological systems. Drug sensitivity data has proven to be a particularly challenging field for identifying associations to inform patient treatment.<h4>Results</h4>To address this, we introduce two semi-parametric variations on the commonly used concordance index: the robust concordance index and ...[more]

PMID: 35585485

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Dataset Information

Evaluation of statistical approaches for association testing in noisy drug screening data.

Background

Results

Conclusions

Publications

Evaluation of statistical approaches for association testing in noisy drug screening data.

Similar Datasets

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