DAB2IP down-regulates HSP90AA1 to inhibit the malignant biological behaviors of colorectal cancer.

ABSTRACT:

Background

Studies have shown that DAB2IP inhibits cancer progression, while HSP90AA1 promotes cancer progression. However, the specific regulatory mechanism of DAB2IP and HSP90AA1 in colorectal cancer (CRC) is not clear. Our aim is to investigate the role and mechanism of DAB2IP and HSP90AA1 in the development of CRC.

Methods

We used bioinformation to analyze the interaction between DAB2IP and HSP90AA1 and predict their downstream pathways. Then, a series of in vitro and in vivo experiments were conducted to reveal the role of DAB2IP and HSP90AA1 in the invasion and metastasis of colorectal cancer, and flow cytometry was used to explore their effects on apoptosis.

Results

Loss of DAB2IP was associated with poor prognosis of CRC. In contrast, elevated expression of HS

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9118737 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature