Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort.

ABSTRACT:

Background

The temporal relationship between adiposity and gut microbiota was unexplored. Whether some gut microbes lie in the pathways from adiposity to insulin resistance is less clear. Our study aims to reveal the temporal relationship between adiposity and gut microbiota and investigate whether gut microbiota may mediate the association of adiposity with insulin resistance in a longitudinal human cohort study.

Methods

We obtained repeated-measured gut shotgun metagenomic and anthropometric data from 426 Chinese participants over ~3 years of follow-up. Cross-lagged path analysis was used to examine the temporal relationship between BMI and gut microbial features. The associations between the gut microbes and insulin resistance-related phenotypes were examined using a line

SUBMITTER: Deng K 

PROVIDER: S-EPMC9118787 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature