Multiple biochemical indices and metabolomics of Clonorchis sinensis provide a novel interpretation of biomarkers.

ABSTRACT:

Background

Clonorchiasis, an infectious disease caused by the liver fluke Clonorchis sinensis, may lead to the development of liver and gallbladder diseases, and even cholangiocarcinoma (CCA). However, the pathogenesis, host-pathogen interaction, and diagnostic markers for clonorchiasis remain unclear.

Methods

Eighteen rabbits were randomly divided into control group (n = 9) and C. sinensis-infected group (n = 9), and their plasma samples were collected at 7, 14, 28, and 63 days post-infection (dpi). Biochemical indices and metabolites in different infection periods were detected. A non-targeted ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was employed to investigate the metabolic profiles of plasma in rabbits, and related metabolic

SUBMITTER: Qiu YY 

PROVIDER: S-EPMC9118806 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature