Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition.

ABSTRACT:

Background

The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membrane rupture at parturition may help identify crucial initiators of parturition for the development of specific strategies to prevent preterm birth, a leading cause of perinatal mortality.

Results

Six major cell types were revealed in human amnion including epithelial cells, fibroblasts and immunocytes as well as three other cell types expressing dual cell markers including epithelial/fibroblast, immune/epithelial and immune/fibroblast markers. The existence of cell types expressing these dual cell markers indicates the presence of epithelial-mesenchymal (EMT),

SUBMITTER: Wang WS 

PROVIDER: S-EPMC9118831 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature