Composite outcomes in observational studies of Crohn's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn's disease and to evaluate whether the number and type of variables included affect the frequency of the outcome.

Methods

MEDLINE [via PubMed], Scopus and Web of Science were searched to identify observational studies that enrolled patients with Crohn's disease and evaluated a composite or aggregate outcome. The proportion of patients achieving the outcome was determined and a random-effects meta-analysis was performed to evaluate how the frequency of each outcome varies according to the reporting of predefined variables.

Results

From 10,257 identified records, 46 were included in the qualitative analysis and 38 in the meta-analysis. The

SUBMITTER: Magro F 

PROVIDER: S-EPMC9118904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature