AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway.

ABSTRACT: A kinase anchor protein 12（AKAP12）is a scaffold protein that is critical for cell structure maintenance and signal transduction. However, the role of AKAP12 in liver injury remains unclear. Here, we attempt to explore the potential contribution of AKAP12 in liver injury and elucidate its underlying molecular mechanism. We found that AKAP12 deletion in acute liver injury (ALI) activates the PI3K/AKT phosphorylation signaling pathway, induces the increased expression of PCSK6 and its downstream inflammation-related genes, and prompts macrophages to produce a large number of inflammatory factors. And knockdown of PCSK6 by in vivo siRNA assay reversed in liver injury AKAP12^Δhep mice, demonstrating that PCSK6 has an important role in ALI. Furthermore, we found that signal transducer

SUBMITTER: Wu X 

PROVIDER: S-EPMC9118925 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature