Evaluating Vitamin D and foxp3 mRNA levels in women with recurrent spontaneous abortion.

ABSTRACT:

Objective

This current survey investigated the role of the Forkhead 3 box protein (foxp3) gene and serum vitamin D levels in women with recurrent spontaneous abortion (RSA).

Methods

The mRNA level of the foxp3 gene in peripheral blood was evaluated in women with a history of RSA (N=40) and in controls (N=40) via quantitative polymerase chain reaction. We employed the enzyme-linked immunosorbent assay to assess the serum levels of 1,25-dihydroxyvitamin D3 (1,25(OH)2 D) in both groups. The Mann-Whitney U test and Pearson's correlation coefficient were used to statistically compare study groups between and within themselves, respectively.

Results

Although mRNA levels of foxp3 were higher in women with RSA than in controls, we observed no significant change in mRNA levels

SUBMITTER: Tafti FD 

PROVIDER: S-EPMC9118952 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature