Particle interactions and their effect on magnetic particle spectroscopy and imaging.

ABSTRACT: Signal stability is crucial for an accurate diagnosis via magnetic particle imaging (MPI). However, MPI-tracer nanoparticles frequently agglomerate during their in vivo applications leading to particle interactions altering the signal. Here, we investigate the influence of such magnetic coupling phenomena on the MPI signal. We prepared Zn_0.4Fe_2.6O₄ nanoparticles by flame spray synthesis and controlled their inter-particle distance by varying SiO₂ coating thickness. The silica shell affected the magnetic properties indicating stronger particle interactions for a smaller inter-particle distance. The SiO₂-coated Zn_0.4Fe_2.6O₄ outperformed the bare sample in magnetic particle spectroscopy (MPS)

SUBMITTER: Moor L 

PROVIDER: S-EPMC9119029 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature