Prostate cancer incidence and survival in relation to prostate cancer as second cancer in relatives.

ABSTRACT:

Objectives

To investigate if the risk of prostate cancer (PC) differs based on the order of primary PC diagnosed in first-degree relatives (FDRs) given possibly different risk factors for PC as first primary cancer (PCa-1) and second primary cancer (PCa-2).

Subjects and methods

In this Swedish nationwide cohort, PC diagnosis was followed for among 149,985 men with one FDR affected by PCa-1, 10,972 with one FDR affected by PCa-2 and 2,896,561 without any FDRs affected by cancer in a maximum of 57 years. PC patients were further followed for death due to PC since diagnosis. Relative risk (RR) of PC was estimated with Poisson regression and hazard ratio (HR) with Cox proportional hazard model.

Results

Compared to men without any FDRs affected by cancer, the RRs of PC in

SUBMITTER: Zheng G 

PROVIDER: S-EPMC9119351 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature