Right hippocampal volume mediation of subjective memory complaints differs by hypertension status in healthy aging.

ABSTRACT: Subjective memory complaints (SMCs) may be an important early indicator of cognitive aging and preclinical Alzheimer's disease risk. This study investigated whether age-related differences in right or left hippocampal volume underlie SMCs, if these relationships differ by hypertension status, and how they are related to objective memory performance in a group of 190 healthy older adults, 50-89 years of age. Analyses revealed a significant mediation of the relationship between age and mild SMCs by right hippocampal volume that was moderated by hypertension status. This moderated mediation effect was not observed with left hippocampal volume. Additionally, a moderated serial mediation model showed that age predicted right hippocampal volume, which predicted SMCs, and in turn predicted object

SUBMITTER: Van Etten EJ 

PROVIDER: S-EPMC9119497 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature