Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection.

ABSTRACT: Herpes simplex virus (HSV) causes chronic infection in the human host, characterized by self-limited episodes of mucosal shedding and lesional disease, with latent infection of neuronal ganglia. The epidemiology of genital herpes has undergone a significant transformation over the past two decades, with the emergence of HSV-1 as a leading cause of first-episode genital herpes in many countries. Though dsDNA viruses are not expected to mutate quickly, it is not yet known to what degree the HSV-1 viral population in a natural host adapts over time, or how often viral population variants are transmitted between hosts. This study provides a comparative genomics analysis for 33 temporally-sampled oral and genital HSV-1 genomes derived from five adult sexual transmission pairs. We found that tra

SUBMITTER: Rathbun MM 

PROVIDER: S-EPMC9119503 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature