Sensitivity of discrete symmetry metrics: Implications for metric choice.

ABSTRACT: Gait asymmetry is present in several pathological populations, including those with Parkinson's disease, Huntington's disease, and stroke survivors. Previous studies suggest that commonly used discrete symmetry metrics, which compare single bilateral variables, may not be equally sensitive to underlying effects of asymmetry, and the use of a metric with low sensitivity could result in unnecessarily low statistical power. The purpose of this study was to provide a comprehensive assessment of the sensitivity of commonly used discrete symmetry metrics to better inform design of future studies. Monte Carlo simulations were used to estimate the statistical power of each symmetry metric at a range of asymmetry magnitudes, group/condition variabilities, and sample sizes. Power was estimated by re

SUBMITTER: Hill A 

PROVIDER: S-EPMC9119531 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature