The impact of the management strategies for patients with subclinical hypothyroidism on long-term clinical outcomes: An umbrella review.

ABSTRACT:

Aim

This umbrella review summarises and compares synthesised evidence on the impact of subclinical hypothyroidism and its management on long-term clinical outcomes.

Methods

We conducted comprehensive searches on MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Database of Systematic Reviews, JBI Evidence Synthesis, the PROSPERO register, Epistemonikos Database and PDQ Evidence from inception to February and July 2021 using keywords on subclinical hypothyroidism, treatment with levothyroxine, monitoring and primary outcomes (all-cause mortality, cardiovascular events, stroke, frailty fractures and quality of life). Only systematic reviews and meta-analyses on adult patient populations were considered. Study selection, data extraction and quality appraisal using AMSTAR-2 were

SUBMITTER: Bauer BS 

PROVIDER: S-EPMC9119548 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature