Dataset Information

Associations between body mass index and bladder cancer survival: Is the obesity paradox short-lived?

ABSTRACT:

Introduction

We investigated the associations of pre-surgical body mass index (BMI) with bladder cancer outcomes in patients treated with radical cystectomy.

Methods

We retrospectively analyzed data from 488 bladder cancer patients treated with radical cystectomy between 1994 and 2007 and followed up until 2016. Cox regression with step function (time-segment analysis) was conducted for overall survival because the proportional hazard assumption was violated.

Results

Of 488 bladder cancer patients, 155 (31.8%) were normal weight, 186 (38.1%) were overweight, and 147 (30.1%) were obese. During the median followup of 59.5 months, 363 (74.4%) patients died, including 197 (40.4%) from bladder cancer. In adjusted Cox regression analyses, BMI was not significantly associated with bladder cancer-specific survival for overweight (hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.57-1.10, p=0.16) or obese (HR 0.76, 95% CI 0.52-1.09, p=0.13) patients. In the Cox regression with step function for overall survival, the time interaction was significant overall (p=0.020) and specifically for over-weight patients (p=0.006). In the time-segment model, the HR for overweight during the first 63 months was 0.66 (95% CI 0.49-0.90, p=0.008), whereas it was 1.41 (95% CI 0.89-2.23, p=0.14) after 63 months. Although not statistically significant, a similar pattern was observed for obese patients.

Conclusions

Our findings suggest that overweight and obese bladder cancer patients had better outcomes within the first five years after radical cystectomy; however, there were no differences in longer-term survival. These data suggest that the obesity paradox in bladder cancer patients treated with radical cystectomy may be short-lived.

SUBMITTER: Arthuso FZ

PROVIDER: S-EPMC9119589 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Associations between body mass index and bladder cancer survival: Is the obesity paradox short-lived?

Arthuso Fernanda Z FZ Fairey Adrian S AS Boulé Normand G NG Courneya Kerry S KS

Canadian Urological Association journal = Journal de l'Association des urologues du Canada 20220501 5

<h4>Introduction</h4>We investigated the associations of pre-surgical body mass index (BMI) with bladder cancer outcomes in patients treated with radical cystectomy.<h4>Methods</h4>We retrospectively analyzed data from 488 bladder cancer patients treated with radical cystectomy between 1994 and 2007 and followed up until 2016. Cox regression with step function (time-segment analysis) was conducted for overall survival because the proportional hazard assumption was violated.<h4>Results</h4>Of 488 ...[more]

PMID: 34941488

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Dataset Information

Associations between body mass index and bladder cancer survival: Is the obesity paradox short-lived?

Introduction

Methods

Results

Conclusions

Publications

Associations between body mass index and bladder cancer survival: Is the obesity paradox short-lived?

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