Multiscale modeling of presynaptic dynamics from molecular to mesoscale.

ABSTRACT: Chemical synapses exhibit a diverse array of internal mechanisms that affect the dynamics of transmission efficacy. Many of these processes, such as release of neurotransmitter and vesicle recycling, depend strongly on activity-dependent influx and accumulation of Ca2+. To model how each of these processes may affect the processing of information in neural circuits, and how their dysfunction may lead to disease states, requires a computationally efficient modelling framework, capable of generating accurate phenomenology without incurring a heavy computational cost per synapse. Constructing a phenomenologically realistic model requires the precise characterization of the timing and probability of neurotransmitter release. Difficulties arise in that functional forms of instantaneous release

SUBMITTER: Garcia JW 

PROVIDER: S-EPMC9119629 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature