A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression.

ABSTRACT: Food intake behavior is regulated by a network of appetite-inducing and appetite-suppressing neuronal populations throughout the brain. The parasubthalamic nucleus (PSTN), a relatively unexplored population of neurons in the posterior hypothalamus, has been hypothesized to regulate appetite due to its connectivity with other anorexigenic neuronal populations and because these neurons express Fos, a marker of neuronal activation, following a meal. However, the individual cell types that make up the PSTN are not well characterized, nor are their functional roles in food intake behavior. Here, we identify and distinguish between two discrete PSTN subpopulations, those that express tachykinin-1 (PSTN^Tac1 neurons) and those that express corticotropin-releasing hormone (PSTN^CRH</

SUBMITTER: Kim JH 

PROVIDER: S-EPMC9119672 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature