Absolute Quantitation of N-Nitrosamines by Coulometric Mass Spectrometry without Using Standards.

ABSTRACT: Carcinogenic N-nitrosamines were recently found in the sartan family of drugs and caused many drug recalls. Both of their detection and quantification are therefore important. Methods reported for N-nitrosamine quantitation rely on the use of standards and are just applicable to simple N-nitrosamines. There is an urgent need to quantify N-nitrosamines derived from drugs with a complicated structure that lack standards. To tackle the issue, this study describes a novel absolute quantitation strategy for N-nitrosamines using coulometric mass spectrometry (CMS) without standards. In our approach, N-nitrosamine is first converted into electrochemically active hydrazine via zinc reduction under acidic condition and the resulting hydrazine can then be ea

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9119692 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature