Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice.

ABSTRACT:

Background

The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely understood.

Materials and methods

To study the in vivo function of osteocyte β1 integrin in bone, we utilized the 10-kb Dmp1 (Dentin matrix acidic phosphoprotein 1)-Cre to generate mice with β1 integrin deletion in this cell type. Micro-computerized tomography, bone histomorphometry and immunohistochemistry were performed to determine the effects of osteocyte β1 integrin loss on bone mass accrual and biomechanical properties. In vivo tibial loading model was applied to study the possible involvement of osteocyte β1 integrin i

SUBMITTER: Qin L 

PROVIDER: S-EPMC9119859 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature