Ontology highlight
ABSTRACT:
SUBMITTER: Miyamoto Y
PROVIDER: S-EPMC9120032 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Miyamoto Yoichi Y Itoh Yumi Y Suzuki Tatsuya T Tanaka Tomohisa T Sakai Yusuke Y Koido Masaru M Hata Chiaki C Wang Cai-Xia CX Otani Mayumi M Moriishi Kohji K Tachibana Taro T Kamatani Yoichiro Y Yoneda Yoshihiro Y Okamoto Toru T Oka Masahiro M
Communications biology 20220519 1
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF6 is an antagonist of interferon (IFN)-mediated antiviral signaling, achieved through the prevention of STAT1 nuclear localization. However, the exact mechanism through which ORF6 prevents STAT1 nuclear trafficking remains unclear. Herein, we demonstrate that ORF6 directly binds to STAT1 with or without IFN stimulation, resulting in the nuclear exclusion of STAT1. ORF6 also recognizes importin α subtypes with different modes, in par ...[more]