Altered hippocampus and amygdala subregion connectome hierarchy in major depressive disorder.

ABSTRACT: The hippocampus and amygdala limbic structures are critical to the etiology of major depressive disorder (MDD). However, there are no high-resolution characterizations of the role of their subregions in the whole brain network (connectome). Connectomic examination of these subregions can uncover disorder-related patterns that are otherwise missed when treated as single structures. 38 MDD patients and 40 healthy controls (HC) underwent anatomical and diffusion imaging using 7-Tesla MRI. Whole-brain segmentation was performed along with hippocampus and amygdala subregion segmentation, each representing a node in the connectome. Graph theory analysis was applied to examine the importance of the limbic subregions within the brain network using centrality features measured by node strength (sum

SUBMITTER: Jacob Y 

PROVIDER: S-EPMC9120054 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature