Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies.

ABSTRACT:

Background

Emerging evidence suggests that dysbiosis in gut microbiota may contribute to the occurrence or development of several rheumatic diseases. Since gut microbiota dysbiosis is potentially modifiable, it has been postulated to be a promising preventive or therapeutic target for rheumatic diseases. However, the current understanding on the potential associations between gut microbiota and rheumatic diseases is still inadequate. Therefore, we aimed to synthesise the accumulating evidence for the relation of gut microbiota to rheumatic diseases.

Methods

The PubMed, Embase and Cochrane Library were searched from inception to March 11, 2022 to include observational studies evaluating the associations between gut microbiota and rheumatic diseases. Standardised mean differen

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9120231 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature