Cross-Frequency Slow Oscillation-Spindle Coupling in a Biophysically Realistic Thalamocortical Neural Mass Model.

ABSTRACT: Sleep manifests itself by the spontaneous emergence of characteristic oscillatory rhythms, which often time-lock and are implicated in memory formation. Here, we analyze a neural mass model of the thalamocortical loop in which the cortical node can generate slow oscillations (approximately 1 Hz) while its thalamic component can generate fast sleep spindles of σ-band activity (12-15 Hz). We study the dynamics for different coupling strengths between the thalamic and cortical nodes, for different conductance values of the thalamic node's potassium leak and hyperpolarization-activated cation-nonselective currents, and for different parameter regimes of the cortical node. The latter are listed as follows: (1) a low activity (DOWN) state with noise-induced, transient excursions into a high acti

SUBMITTER: Jajcay N 

PROVIDER: S-EPMC9120371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature