Two waves of coeliac disease incidence in Sweden: a nationwide population-based cohort study from 1990 to 2015.

ABSTRACT:

Objectives

To assess the incidence of biopsy-verified coeliac disease (CD) in Sweden and examine the incidence of duodenal/jejunal biopsies with normal mucosa over time as a proxy for CD awareness and investigation.

Design

Nationwide population-based cohort study 1990-2015 based on biopsy reports indicating villous atrophy (VA) or normal mucosa in the duodenum/jejunum.

Results

We identified 44 771 individuals (63% females) with a biopsy report specifying VA and 412 279 (62% females) with a biopsy report indicating normal mucosa (without a prior biopsy indicating VA). The median age at diagnosis of CD was 28 years. The mean age-standardised incidence rate during the study period was 19.0 per 100 000 person-years (95% CI 17.3 to 20.8). The incidence reached a peak in 19

SUBMITTER: Bergman D 

PROVIDER: S-EPMC9120400 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature