Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis.

ABSTRACT:

Background

Inflammation and immune dysfunction play significant roles in the pathogenesis of Alzheimer's disease (AD)-related dementia. Changes in peripheral blood cell profiles are a common manifestation of inflammation and immune dysfunction and have been reported in patients with AD or mild cognitive impairment (MCI). We systematically evaluated the association of peripheral blood cell counts and indices with AD or MCI through a meta-analysis.

Methods

We electronically searched sources to identify all case-control trials comparing peripheral blood cell counts and/or lymphocyte subsets between patients with AD or MCI and healthy controls (HCs). Meta-analyses were used to estimate the between-group standardized mean difference (SMD) and 95% confidence interval (CI).

Resu

SUBMITTER: Huang LT 

PROVIDER: S-EPMC9120416 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature