Cocaine-Induced Locomotor Activation Differs Across Inbred Mouse Substrains.

ABSTRACT: Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societal burden, but there are currently no FDA-approved therapies. The development of novel and effective treatments has been hindered by substantial gaps in our knowledge about the etiology of these disorders. The risk for developing a CUD is influenced by genetics, the environment and complex interactions between the two. Identifying specific genes and environmental risk factors that increase CUD risk would provide an avenue for the development of novel treatments. Rodent models of addiction-relevant behaviors have been a valuable tool for studying the genetics of behavioral responses to drugs of abuse. Traditional genetic mapping using genetically and phenotypically divergent inbred mice has b

SUBMITTER: Gaines CH 

PROVIDER: S-EPMC9120424 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature