Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1α.

ABSTRACT:

Background

Korean Red Ginseng extract (KRGE) has been used as a health supplement and herbal medicine. Astrocytes are one of the key cells in the central nervous system (CNS) and have bioenergetic potential as they stimulate mitochondrial biogenesis. They play a critical role in connecting the brain vasculature and nerves in the CNS.

Methods

Brain samples from KRGE-administered mice were tested using immunohistochemistry. Treatment of human brain astrocytes with KRGE was subjected to assays such as proliferation, cytotoxicity, Mitotracker, ATP production, and O₂ consumption rate as well as western blotting to demonstrate the expression of proteins related to mitochondria functions. The expression of hypoxia-inducible factor-1α (HIF-1α) was diminished utilizing siR

SUBMITTER: Park J 

PROVIDER: S-EPMC9120627 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature