Sex-Related Differences in the Immune Response to Meningococcal Vaccinations During Adolescence.

ABSTRACT:

Background

Immune responses to pediatric vaccinations have been reported to differ according to sex. Such sex-differential responses may become more pronounced during adolescence due to hormonal differences. We investigated whether the vaccine response following primary vaccination against meningococcal serogroup A (MenA), MenW and MenY and booster vaccination against MenC differed between girls and boys using data from two clinical studies.

Methods

Children aged 10, 12, and 15 years, who had been primed with MenC vaccination between 14 months and 6 years of age, received a booster MenC vaccination or MenACWY vaccination. Polysaccharide-specific IgG concentrations and functional antibody titers [determined with the serum bactericidal antibody (SBA) assay] were measured at ba

SUBMITTER: Ohm M 

PROVIDER: S-EPMC9120633 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature