Comparative antiplatelet and antithrombotic effects of red ginseng and fermented red ginseng extracts.

ABSTRACT:

Background

Fermentation may alter the bioavailability of certain compounds, which may affect their efficacy and pharmacological responses. This study investigated the antiplatelet effects of red ginseng extract (RGE) and fermented red ginseng extract (FRG).

Methods

A rodent model was used to evaluate the antiplatelet and antithrombotic effects of the extracts. Rats were orally fed with human equivalent doses of the extracts for 1 week and examined for various signaling pathways using standard in vivo and ex vivo techniques. Light transmission aggregometry was performed, and calcium mobilization, dense granule secretion, integrin α_IIbβ₃-mediated signaling molecules, cyclic nucleotide signaling events, and various protein molecules were evaluated ex vivo

SUBMITTER: Irfan M 

PROVIDER: S-EPMC9120646 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature