Alterations in resting-state whole-brain functional connectivity pattern similarity in bipolar disorder patients.

ABSTRACT:

Background

Previous neuroimaging studies have extensively demonstrated many signs of functionally spontaneous local neural activity abnormalities in bipolar disorder (BD) patients using resting-state functional magnetic resonance imaging (rs-fMRI). However, how to identify the changes of voxel-wise whole-brain functional connectivity pattern and its corresponding functional connectivity changes remain largely unclear in BD patients. The current study aimed to investigate the voxel-wise changes of functional connectivity patterns in BD patients using publicly available data from the UCLA CNP LA5c Study.

Methods

A total of 45 BD patients and 115 healthy control subjects were finally included and whole-brain functional connectivity homogeneity (FcHo) was calculated from their r

SUBMITTER: Ping L 

PROVIDER: S-EPMC9120726 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature