Bridging structural and functional biomarkers in functional movement disorder using network mapping.

ABSTRACT:

Background

There are gaps in our neurobiological understanding of functional movement disorder (FMD).

Objectives

We investigated gray matter volumetric profiles in FMD, and related findings to resting-state functional connectivity (rsFC) profiles using Human Connectome Project data.

Methods

Volumetric differences between 53 FMD patients and 50 controls were examined, as well as relationships between individual differences in FMD symptom severity and volumetric profiles. Atrophy network mapping was also used to probe whether FMD-related structural alterations preferentially impacted brain areas with dense rsFC.

Results

Compared to controls without neurological comorbidities (albeit with mild depression and anxiety as a group), the FMD cohort did not show any vol

SUBMITTER: Sojka P 

PROVIDER: S-EPMC9120728 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature