On the recovery of disorders of consciousness under intrathecal baclofen administration for severe spasticity-An observational study.

ABSTRACT:

Background

Occasionally, patients show dramatic recovery from disorders of consciousness (DOC) under intrathecal baclofen (ITB), an established treatment option for severe supraspinal spasticity. Anecdotal explanations for ITB-related recovery of cognition include modulation of afferent impulses at the spinal level, thereby reducing spasticity-related proprioceptive information overload within cortico-thalamo-cortical connections.

Objective

In this retrospective patient chart analysis, we assessed whether a reduction in spasticity would be associated with an increase in Coma Recovery Scale revised (CRS-R) scores in a larger sample of patients than previously published.

Methods

From a hospital-based ITB treatment register, we extracted data from 26 patients with DOC an

SUBMITTER: Halbmayer LM 

PROVIDER: S-EPMC9120732 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature