Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression.

ABSTRACT:

Background

Although the tumor-suppressive effects of ginsenosides in cell cycle have been well established, their pharmacological properties in mitosis have not been clarified yet. The chromosomal instability resulting from dysregulated mitotic processes is usually increased in cancer. In this study, we aimed to investigate the anticancer effects of ginsenoside Rg1 on mitotic progression in cancer.

Materials and methods

Cancer cells were treated with ginsenoside Rg1 and their morphology and intensity of different protein were analyzed using immunofluorescence microscopy. The level of proteins in chromosomes was compared through chromosomal fractionation and Western blot analyses. The location and intensity of proteins in the chromosome were confirmed through immunostaining o

SUBMITTER: Hong J 

PROVIDER: S-EPMC9120780 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature