Low NAD⁺ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice.

ABSTRACT: Advanced paternal age has increasingly been recognized as a risk factor for male fertility and progeny health. While underlying causes are not well understood, aging is associated with a continuous decline of blood and tissue NAD⁺ levels, as well as a decline of testicular functions. The important basic question to what extent ageing-related NAD⁺ decline is functionally linked to decreased male fertility has been difficult to address due to the pleiotropic effects of aging, and the lack of a suitable animal model in which NAD⁺ levels can be lowered experimentally in chronologically young adult males. We therefore developed a transgenic mouse model of acquired niacin dependency (ANDY), in which NAD⁺ levels can be experimentally lowered using a nia

SUBMITTER: Meyer-Ficca ML 

PROVIDER: S-EPMC9120959 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature