Neural Markers of Methylphenidate Response in Children With Attention Deficit Hyperactivity Disorder.

ABSTRACT:

Background

Despite widespread use of stimulants to treat ADHD, individual responses vary considerably and few predictors of response have been identified. The identification of reliable and clinically feasible biomarkers would facilitate a precision medicine approach to pharmacological treatment of ADHD. We test the hypothesis that two electroencephalography (EEG) based neural signatures of ADHD, resting aperiodic slope exponent and novelty P3 amplitude, are markers of methylphenidate response in children. We hypothesize that positive response to methylphenidate treatment will be associated with greater abnormality of both neural markers.

Methods

Twenty-nine 7-11 year-old children with ADHD and a history of methylphenidate treatment, and 30 controls completed resting EEG and

SUBMITTER: Arnett AB 

PROVIDER: S-EPMC9121006 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature