The Risk of Nonunion in Smokers Revisited: A Systematic Review and Meta-Analysis.

ABSTRACT:

Study design

Systemic review and meta-analysis.

Objective

To review and establish the effect of tobacco smoking on risk of nonunion following spinal fusion.

Methods

A systematic search of Medline, Embase, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews from inception to December 31, 2020, was conducted. Cohort studies directly comparing smokers with nonsmokers that provided the number of nonunions and fused segments were included. Following data extraction, the risk of bias was assessed using the Quality in Prognosis Studies Tool, and the strength of evidence for nonunion was evaluated using the GRADE working group criteria. All data analysis was performed in Review Manager 5, and a random effects model was used.

Resu

SUBMITTER: Nunna RS 

PROVIDER: S-EPMC9121161 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature